ACP Journal Club. Clinically indicated and routine replacement of peripheral IV catheters did not differ for phlebitis.

Outcomes: Primary outcome was phlebitis during use or within 48 hours of catheter removal. Phlebitis was defined as simultaneous presentation of ≥ 2 of the following: patient-reported pain or tenderness, with severity ≥ 2 on a 10-point scale; erythema extending ≥ 1 cm from insertion site; swelling extending ≥ 1 cm from insertion site; purulent discharge; or palpable venous cord beyond the catheter tip. 3000 patients were needed to detect equivalence of therapies at 4% phlebitis (equivalence margin 3%) with 95% power (α = 0.05).